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Breast Cancer 5m 55s

Immunotherapy in Metastatic Breast Cancer

Published 30 Aug 2022
With higher rates of TILs, PD-L1 expression & tumour mutational burden immunotherapy was always waiting to be explored in mTNBC.

Early clinical trials studying single agent Immunotherapy with Pembrolizumab and Atezolizumab for mTNBC showed long-lasting responses in some patients and notably in 1st line of treatment.
In Nov.2020 based on results Keynote 355 study, FDA granted accelerated approval to Pembrolizumab in combination with chemotherapy for patients with mTNBC whose tumors expressed PDL1(CPS>10) as determined by FDA approved rest.
In August 2021, initial approval of Atezolizumab with nab -Paclitaxel in mTNBC was withdrawn as continued approval was dependent on IMpassion -131 clinical trial meeting PFS as an end point.
Immunotherapy for mTNBC has brought significant improvement in treatment outcomes for PDL1 positive patients.
immunotherapy keynote -355 metastatic triple negative breast cancer

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