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Oncology 13m 25s

Are we ready to consider tissue agnostic treatment options in Solid Tumors

Published 11 Jul 2022
Actionable oncogenic mutations have revolutionized the treatment of many solid tumors. From the treatment driven by Biomarker derived population we are moving to tumor agnostic treatment based on shared molecular abnormality. Basket clinical trials are being carried out in patients with different tumor types but similar genetic abnormality. NTRK inhibitors targeting NTRK fusions are currently approved by FDA in tissue-agnostic way. Mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) cancers can be treated with the programmed cell death 1 (PD-1) antibody like pembrolizumab.
anti pd1 antibody msi high cancers ntrk inhibitors personalized medicine tissue agnostic treatment

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