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Myelodysplastic Syndromes 3m 18s

Anemia of MDS

Published 04 Oct 2022
Anemia is common feature of MDS with 90% patients having anemia at diagnosis or initial presentation. Anemia not only impacts quality of life but is also prognostic in nature.
Transfusion dependent MDS patients have worse prognosis compared to transfusion independent patients. Iron overload associated with transfusion dependence contributes to worse prognosis. Low risk patients are often treated with Erythropoietin, Luspatercept can considered for patients with ring sideroblasts while high risk patients are treated with Hypomethylating agents. Lenalidomide is particularly useful for patients with Del 5-q abnormality.
anemia mds transfusion dependence

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