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Breast Cancer 11m 43s

Sequencing of treatment for Her2 positive MBC in 2022

Published 07 Jul 2022
Noteworthy treatment options added in the treatment guidelines for Her2 positive MBC are Trastuzumab Deruxtecan (TDXd) and combination of Trastuzumab + Capecitabine +Tucatinib. In landmark Destiny Breast 03 study TDXd showed significant PFS benefit compared to TDM1 in Her2 positive MBC patients who have received prior Trastuzumab and Taxane. HER2CLIMB study showed significant PFS & OS benefit for combination of Trastuzumab + Capecitabine +Tucatinib and retained significant activity in patients with brain metastases not requiring immediate treatment.
brain metastases her2 positive mbc trastuzumab deruxtecan tucatinib

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