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Breast Cancer 11m 43s

Sequencing of treatment for Her2 positive MBC in 2022

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Published 07 Jul 2022
Noteworthy treatment options added in the treatment guidelines for Her2 positive MBC are Trastuzumab Deruxtecan (TDXd) and combination of Trastuzumab + Capecitabine +Tucatinib. In landmark Destiny Breast 03 study TDXd showed significant PFS benefit compared to TDM1 in Her2 positive MBC patients who have received prior Trastuzumab and Taxane. HER2CLIMB study showed significant PFS & OS benefit for combination of Trastuzumab + Capecitabine +Tucatinib and retained significant activity in patients with brain metastases not requiring immediate treatment.
brain metastases her2 positive mbc trastuzumab deruxtecan tucatinib

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